Berberina i els seus derivats

La berberina és un compost alcaloid aïlat d'herbes medicinals i que mostra una activitat farmacològica diversa. Encara que les bases moleculars de la seva activitat biològica continuen essent objecte de debat, es continua acumulant informació sobre la molècula, dades que seran aprofitades per a futures aplicacions a la clínica. Entre les aplicacions terapèutiques que han obert millors expectatives i interès per part dels científics destanquen les relacionades amb malaltia cardiovascular, la síndrome metabòlica i el càncer. Malgrat aquesta activitat, la seva baixa absorció i biodisponibilitat limite el seu ús terapèutic per lo que en els darrers anys s'han dissenyat nous derivats que milloran les seves propietats farmacològiques, per avançar en el seu ús a la clínica. 

Publicacions rellevants en l'àrea de recerca


Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells-Power of nutraceuticals

McCubrey JA, Abrams SL, Lertpiriyapong K, Cocco L, Ratti S, Martelli AM, Candido S, Libra M, Murata RM, Rosalen PL, Lombardi P, Montalto G, Cervello M, Gizak A, Rakus D, Steelman LS. 
Adv Biol Regul. Jan 2018.

Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed... see publication


Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB.

Vieira S, Castelli S, Falconi M, Takarada J, Fiorillo G, Buzzetti F, Lombardi P, Desideri A. 
Int J Biol Macromol. 2015.

Topoisomerases IB are anticancer and antimicrobial targets whose inhibition by several natural and non-natural compounds has been documented. The inhibition effect by berberine and some 13-(di)phenylalkyl berberine derivatives has been tested towards... see publication


Multiple effects of berberine derivatives on colon cancer cells.

Guamán Ortiz LM, Tillhon M, Parks M, Dutto I, Prosperi E, Savio M, Arcamone AG, Buzzetti F, Lombardi P, Scovassi AI. 
Biomed Res Int. 2014.

The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine... see publication


Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives.

Albring KF, Weidemüller J, Mittag S, Weiske J, Friedrich K, Geroni MC, Lombardi P, Huber O. 
Biofactors 2013.

Aberrant activation of the canonical Wnt/β-catenin signaling pathway has been reported for numerous tumors of different origins. In most cases, mutations in components of the Wnt signaling pathway or in β-catenin itself were detected which ultimately... see publication


Antitumor effect of novel berberine derivatives in breast cancer cells.

Pierpaoli E, Arcamone AG, Buzzetti F, Lombardi P, Salvatore C, Provinciali M. 
Biofactors 2013.

Breast cancer is the most common malignancy and the most common cause of cancer death in elderly women. Chemoprevention with dietary compounds and their synthetic analogs has emerged as an attractive strategy to prevent carcinogenic progression to... see publication


Berberine: new perspectives for old remedies.

Tillhon M, Guamán Ortiz LM, Lombardi P, Scovassi AI. 
Biochem Pharmacol. 2012.

Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. Among them, the natural isoquinoline alkaloid berberine has been employed in Ayurvedic and Chinese Medicine for hundreds of... see publication

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